Danny Ings gave Southampton a surprise 1-0 home win over Premier League leaders Liverpool.
Liverpool prevailed to equal the record of 18 consecutive top-flight wins set by Manchester City in 2017.
Alexander-Arnold, seeing the Spanish club's defenders still getting organised, feigned to walk away from the corner before racing back to whip the ball to the unmarked Divock Origi, who clipped it past Marc-Andre ter Stegen.
Images from Sunday's action in the Premier League.
This was not quite Liverpool back to their best but it was an important statement of intent for Klopp's side that they will not be giving up their title without a fight.
Liverpool beat Cardiff City side 3-1 in the FA Cup on Sunday
Liverpool's English Premier League title winning captain Jordan Henderson was named England's Footballer of the Year on Friday in the annual vote of the Football Writers' Association (FWA).
It is a first win in six games in all competitions for Liverpool.
While England boast a formidable attacking threat, there are concerns about their defence which is perhaps why Southgate is prepared to look at new candidates before he has to make his final call for the tournament.
The goal was checked by VAR and allowed to stand as Liverpool went on to clinch the victory and move nine points clear of City in the Premier League title race.
Images from Saturday's action in the Premier League.
News of all that transpired on and off the football field
Diogo Jota's doubled earned Juergen Klopp's side a 2-0 victory over Leicester City
This is Real Madrid's third consecutive Champions League title.
Twenty-year-old Conor Bradley scored his first goal for Liverpool and claimed two assists as Juergen Klopp's team moved five points clear at the top
News of all that's transpired on and off the football field
Images from the UEFA Champions League matches played on Tuesday
IMAGES from the Premier League matches played on Sunday
Liverpool stuttered into the quarter-finals of the Champions League with a 2-1 aggregate win over Inter Milan after suffering a 1-0 loss to the Italian side, who were reduced to 10 men, at Anfield on Tuesday.
Salah himself blasted home the spot-kick and Leeds looked as though they may be in for a very long day.
With his calm guidance, Ancelotti gave Vinicius the confidence he needed to flourish.
A summary of Saturday's action in the English Premier League.
An own goal and a Sadio Mane strike earned Liverpool a 2-0 victory in their Champions League semi-final first-leg against Villarreal on Wednesday, putting Juergen Klopp's side on course for their third European Cup final in five seasons.
Klopp's side won the Champions League, Super Cup and Club World Cup titles last year, but the German said that their rivals will look to close the gap.
Klopp says Liverpool's defending to blame for loss
Marcus Rashford and Joshua Zirkzee bagged two goals apiece as Manchester United thumped Everton 4-0 on Sunday in new manager Ruben Amorim's first Premier League match at Old Trafford.
Liverpool raised the bar so high and enjoyed such a huge winning margin in claiming the English Premier League title last season it would be churlish to doubt their credentials for a repeat showing.
England's keeper Jordan Pickford scored and saved in a shootout as they beat Switzerland 6-5 on penalties to finish third in the Nations League on Sunday
Images from Sunday's action in the Premier League
Liverpool could be crowned champions of England for the first time in 30 years, on Wednesday, having turned the Premier League title race into a procession.
Liverpool reclaimed top spot in the Premier League with a 3-1 win over Burnley at Anfield on Saturday, but they were made to battle hard by a brave visiting side.
Kevin De Bruyne had to be replaced by Gabriel Jesus in the 60th minute on Saturday following a collision with Antonio Rudiger.
Brentford pulled off their latest English Premier League shock by beating Liverpool 3-1 at home.
'For the Premier League, it would be great having the best player in the world in the league. I'm not sure the Premier League needs a boost but it would be.'
Jurgen Klopp has agreed a contract extension with Liverpool until 2024
An 87th-minute header from defender Diego Llorente gave Leeds United a 1-1 home draw with Liverpool in the Premier League on Monday after the home side staged a protest against the breakaway Super League prior to the kickoff.
Images from EPL matches played on Wednesday
France qualified for the quarter-finals of the Nations League despite a lacklustre goalless draw against Israel on Thursday.
Vinicius Junior's second half tap-in steered Real Madrid to a 1-0 victory over Liverpool in the Champions League final on Saturday.